The first draw I did at 12 weeks and second draw did at around 13 weeks 6 days. Yes, NIPT can be done anytime after 10 weeks of pregnancy. I had an inconclusive harmony test at 10 weeks exactly, I wasn't too worried as it was really early, I was on blood thinners, and a higher bmi of 30, all of which can lead to an inconclusive result. Is this an ivf pregnancy? Overwhelmed and frustrated by weight gain. Unlike most DNA, which is found inside a cell's . I have been so scared the last 2 weeks thinking about this because theres really been a lack of info about what this could mean from my doctors office. Please specify a reason for deleting this reply from the community. My nipt/panorama/harmony results came back inconclusive both times. praying for you and your son or daughter to receive good results! Ive done nipt through generations and Harmony both reputable brands and they would never give results with that low of a fraction, as it could come from contamination from say, the person drawing the bloods or the one analysing touching the tube to read results. Would I consider diagnostic tests like amniocentesis or CVS? Hey lovely - where are you based? Create an account or log in to participate. Group Leaders arent expected to spend any additional time in the community, and are not held to a set schedule. We strive to provide you with a high quality community experience. It just means they don't have enough information to make any kind of conclusion. Check with your insurance provider before testing to be sure. I also did NIPT twice and bouth times it came back inconclusive due to low fetal fraction. Press question mark to learn the rest of the keyboard shortcuts, third time mom / due aug 2023 / 30 / she/her. K/!0p8v?vbs#.TOc %>.n>pJKps,m0T7-r*Y:p HB&~=^D_|+wIG0s(i]A[p{{9lfvrXiOsd$f{U&K>VY?-3K?gHG|;%nG\O#@'u}mtlDFCgoo>oH![mM*rYauM('@6Gsyc1ER91`o8vk@02>n]FFPl?#=p""?qoir7.[ RU'^G'ulAI$EW0]_.6L8Le. Ive heard where some people have a hard time getting results depending on their weight.. Friend opening my baby items for their own baby. 1997-2023 BabyCenter, LLC, a Ziff Davis company. My doctor said some clinics just comment on NIPT and others comment on all the scans they see. The test is slightly less accurate for detecting trisomy 18 and 13. Obviously not out of the woods but the good news is all I needed to keep tracking forward with positivity. Hi ladies,So I just had a call that my Harmony retest has come back inconclusive. You definitely are not obese! I was 11 weeks and 12.5 weeks for mine. SMFM 2015: A failed result on noninvasive prenatal testing (NIPT) may provide insight into what subsequent tests may find, research reveals. I wish you well mama! Hi friend. The educational health content on What To Expect is reviewed by our medical review board and team of experts to be up-to-date and in line with the latest evidence-based medical information and accepted health guidelines, including the medically reviewed What to Expect books by Heidi Murkoff. Mumsnet carries some affiliate marketing links, so if you buy something through our posts, we may get a small share of the sale (more details here). also people mentioned placenta issues above! By accepting all cookies, you agree to our use of cookies to deliver and maintain our services and site, improve the quality of Reddit, personalize Reddit content and advertising, and measure the effectiveness of advertising. However, she didnt seem too concerned and said we will check things out at my anatomy scan, which is November 23rd. It took 6 weeks and a lot of worry, so ask for the SAFE if they have it? I called the doctors office today to check on my second Panorama test and they informed the test came back again inconclusive due to low fetal fraction. If you dont have insurance or your insurance doesnt cover NIPT tests, you can pay for the test. The views expressed in community are solely the opinions of participants, and do not reflect those of What to Expect. Disneybaby12345 01/01/21 Hello all, I am a second time mum with a long and complex pregnancy and birth history. I was 164 pre pregnancy and 184 now. Prenatal tests like NIPT are optional, and getting the test is entirely up to you. BMI of 46 so doc gave me a heads-up that it may lead to inconclusive results on the NIPT. But that's my personal non-expert opinion. (https://www.smfm.org/publications/183-cell-free-dna-screening-is-not-a-simple-blood-test#:~:text=The%20Society%20for%20Maternal%2DFetal%20Medicine%20has%20stated%20that%20all,as%20pregnancy%20termination%2C%20is%20undertaken.). Has anyone experienced this? All rights reserved. I waited 13 days for my Harmony test results and the nurse finally called me back today to tell me my test was inconclusive! NIPT cant screen for all chromosomal or genetic conditions. And if so, what are you going to do? Hi ladies,So I just had a call that my Harmony retest has come back inconclusive. I also have a bloodclot that I am on Lovenox for which adjust my blood levels, could this effect these results? Now at 16w they were both under 2. 4% at least is needed for accuracy. It doesnt diagnose a condition. I wouldnt have survived with out those ladies. The first draw I did at 12 weeks and second draw did at around 13 weeks 6 days. Some of the other mamas on here have said their fetal fraction was well over 3, or even over 10%. First test, done at 12 weeks, took 2 weeks for them to get back to me and say was inconclusive, so I had a redraw a week and a half ago at 14 weeks. . Has anyone had the test come out inconclusive twice? Praise post for amazing husbands and good in-laws. Use of this site is subject to our terms of use and privacy policy. Are you taking aspirin? Well this clinic doesnt ask people to come back. Its done by taking a sample of your blood, which also contains fragments of DNA from the fetus. 0 We do not endorse non-Cleveland Clinic products or services. I didn't know size may have factored into it, thanks for sharing! Its important that you talk to your healthcare provider about your results and options to get more information. My doctor didnt seem too concerned, as apparently they come back inconclusive all the time. k[oku6Av9j12U}BOn.jQ5-W],W7N~x ;)R7M 9z:FC& Q~Ro1!. Well, my redraw came back inconclusive, but the NT ultrasounds were reassuring (I am carrying twins). Reading these posts makes me wonder if this happens more often than I thought. Group Black's collective includes Essence, The Shade Room and Naturally Curly. We had issues with our genetic testing as well and I too was super worried! I was also severely anemic and dehydrated due to hyperemesis gravidum. Originally my doctor said we would take another blood sample once I was further along around 16 weeks and try again if it didn't work initially. This educational content is not medical or diagnostic advice. Thats why the screening isnt performed until 10 weeks into the pregnancy. Your cells are constantly dividing and creating new cells. The first rest was done around 10 weeks and the second around 14 weeks. Your post will be hidden and deleted by moderators. It took 6 weeks and a lot of worry, so ask for the SAFE if they have it? I did my NIPT bloodwork at 9w 4d and am supposed to have my results back this Friday. Press question mark to learn the rest of the keyboard shortcuts. The educational health content on What To Expect is reviewed by our medical review board and team of experts to be up-to-date and in line with the latest evidence-based medical information and accepted health guidelines, including the medically reviewed What to Expect books by Heidi Murkoff. They didn't even bother to retest mine when the first try came back inconclusive because they assumed it wouldn't work since I'm obese. Has anyone had this? Eleniada 29/03/21 Has anyone had NIPT come back inconclusive twice??? Mine came back inconclusive also. Which is less than it would normally be for my age. Cleveland Clinic is a non-profit academic medical center. What to Expect supports Group Black and its mission to increase greater diversity in media voices and media ownership. Group Black's collective includes Essence, The Shade Room and Naturally Curly. I dont understand why it didnt work for me. Note that once you confirm, this action cannot be undone. Certain prenatal screening tests like NIPT are very accurate for conditions such as Down syndrome, but less so for rare genetic conditions. First test taken 10w3days, second taken 13w3days. you can always do amnio if you need results. When I went back for a second blood draw, they took two tubes of blood. Learn more about, Twins & Multiples: Your Tentative Time Table. This is a red flag for chromosomal Natera NIPT 2nd Try Results. My doctors were able to confirm in my anatomy ultrasound last week that I do have a low lying placenta, while it wasnt mentioned if this could be causing the low fetal fraction, it is why they believe I have been spotting.. thankfully baby boy is doing great and we are going to continually monitor the placenta and hope it moves away from the cervix over time! NIPT doesnt test for all chromosomal conditions or birth disorders. I dont have any advice. The CVS came back perfect - no abnormalities. I am way larger than you. Lol. :). The minimum they require to release the results is 2.8%, and the first draw I had 3.2% for 1 baby and 2.2% for the other. Same thing happened to me. But I was told they like to comment on everything they see based on the technicians scans. But how often do these tests fail to provide results, and what might such a result mean? I have read this is an issue for plus size women and . Both said due to low fetal DNA at 2.6% and 2.7% respectively. It can't do genetic risks though. Good luck to you! How do health care providers diagnose birth defects? As far as 16 weeks ultrasound, sex was pretty obvious on mine . NIPT is a screening test and, therefore, isnt perfect. Overall, NIPT tests produce fewer false positives than other prenatal screenings like the quad screen. So I just found out that my NIPT came back with low fetal fraction for the second time. My anatomy scan went well and the doctor has no other concerns at this point. Good luck!! The first time it came back inconclusive due to low fetal fraction. Please select a reason for escalating this post to the WTE moderators: Connect with our community members by starting a discussion. I've had the draw twice and thencutoff for weight to be an issue is 250 and I'm 170 so they say that's not the issue :(. The test can also determine the sex of the fetus. I have never heard of two inconclusive results! My doc told me 2 inconclusive tests raises the risk level significantly in my age. Were you referring to the harmony test? Are you doing the NT scan & bloods as well? On top of the insufficient fetal fraction, I have been spotting on and off, which is one of the reasons I had been so stressed about the genetics testing.. wanting to make sure something wasnt wrong with baby. Getting a noninvasive pregnancy screening or other prenatal genetic test is up to you. Hi all, just an update. I ended up asking for a quad screen (it wasnt covered by my insurance but was like $30) to assess risk for trisomy 21, 18 and spina bifida. My BMI is a bit high and I've read that can be a reason. I did have the nt scan with the dr and she said everything looked good and chances for down syndrome was very low but now im panicking I donr know why this could happen. We strive to provide you with a high quality community experience. A Group Leader is a What to Expect community member who has been selected by our staff to help maintain a positive, supportive tone within a group. 19 weeks tomorrow. thank you - apparently triploidy is not linked to maternal age - Im 29 and it could have happened to an 18 year old or a 40 year old mother. I found out the gender at 16 weeks and BMI was 42 x. I will likely decline invasive testing like amniocentesis. I have also read that certain medications can interfere so that is totally possible that its what happened in your case. All rights reserved. I was super annoyed, but Im taking her word and hoping all is fine. Your DNA is inside all of your cells. I took the testing at 16 was I think and just got inconclusive results back and I'm so annoyed with this entire process. Had my redraw at 13+2, and results have come back the same, inconclusive due to low fetal fraction. However my 12 weeks NT scan and EFTS blood test both came back normal/ low . Your healthcare provider can answer any questions you have, but ultimately you have to decide how a genetic or chromosomal disorder affects you and your family based on your situation. Has anyone had this happen to them or know someone? - May 2020 Babies | Forums | What to Expect Community > Birth Month May 2020 Babies 97K Discussions 192K Members The views expressed in community are solely the opinions of participants, and do not reflect those of What to Expect. Just wanted to share my experience since Ive gotten both a CVS and an amniocentesis in the last 3 weeks.Backstory: at my 12 week nuchal translucency scan, we had a high measurement of nuchal fluid (3.5mm). In this case, you can repeat the NIPT test and hope for a result the second time. We had two failed harmony results, both came back inconclusive because of low dna fraction. I had the first done at 13w and second done at 16w. My first test was at 10 weeks (FF=4.8%) and my second was at 14 weeks-she didnt tell me over the phone what it was. The main purpose of NIPT is to screen for major chromosome conditions (Down syndrome, trisomy 18, and trisomy 13). I feel like Im holding myself together for now but that I can brake at any point so very wary of how I will deal with a second loss in a row :(. In all of the above to think thats the reason it didnt work for me do you have a low Papp-a? All rights reserved. For example, you may get a positive or high-risk result for trisomy 13 but a negative or low-risk result for Down syndrome. This educational content is not medical or diagnostic advice. This time around I used Myriad Prequel, which has a technology that prevents most (maybe all?) Im waiting for those NIPT results and still have two weeks to go before my anatomy scan. Press J to jump to the feed. Cleveland Clinics Ob/Gyn & Womens Health Institute is committed to providing world-class care for women of all ages. The DNA is examined for genetic conditions, such as Down syndrome. Many factors may go into your decision to have NIPT and prenatal genetic testing in general. Please whitelist our site to get all the best deals and offers from our partners. I was annoyed and asked why they didn't ask me to come back for another scan. Lab is saying I could try a third time but no guarantees it will work. https://amp.reddit.com/r/NIPT/comments/ecjj5v/welcome_to_rnipt_the_sub_for_abnormal_nipt/, the most helpful and trustworthy pregnancy and parenting information. Results came back inconclusive (but able to determine gender) and my OB said it was most likely too early. We strive to provide you with a high quality community experience. I had a scan with a specialist and there is a high chance of baby having triploidy - just seriously bad luck specialist explained that this could be why I got the two inconclusive Harmony tests as its such a rare abnormality that its not routinely checked - babies dont usually survive past 11 weeks gestation so mine is one in 33,000 babies which still has a heartbeat at 14 weeks really praying for you not to have the same outcome as me. Had to redraw today and start the waiting process all over. My first pregnancy resulted in a miscarriage at 8 weeks. Your provider obtains a blood sample through a vein in your arm. rU%`_@j)4KYm9"PR Xb@{i#n->`#4sI2n# ! NIPT also includes a study of the sex chromosomes, but a result is not always possible. The #1 app for tracking pregnancy and baby growth. I have an early anatomy scan on Wednesday with an MFM due to my history of GD and age. It is super frustrating, and I think honestly more frustrating that docs continue to recommend these tests when it seems like everyone I know with a high BMI had this issue. I think if the scan/bloods come back clear then I wont do a third one (just more worry/waiting) but if there is anything not good I will have to decide to either do a third NIPT or more invasive procedures (which I would really want to avoid!). insufficient DNA for the NIPT test) and chances of a trisomy defect. Policy. I did have the nt scan with the dr and she said everything looked good and chances for down syndrome was very low but now im panicking I donr know . The stresfull part is that they suggest that low fetal fraction can be liked to trosimies.. I'm panicking now because I'm so worried. If you'd continue the pregnancy regardless of any defects, then I think you can definitely skip the amnio. The result will show if theres an increased or decreased risk for a fetus to have the condition being screened. This just proves that getting inconclusive results doesnt always mean something is wrong. My doctor told me to test then and acted as if that wasnt too early. My risk just due age is 1/94 for trisomy 13, 18. Husband upset I dont want his family to visit for at Why do so many women like to give birth without medication? Create an account to follow your favorite communities and start taking part in conversations. Dont be afraid to ask questions. %%EOF My doc told me 2 inconclusive tests raises the risk level significantly in my age. I done alot of research into NIPT before going for it and knew a high BMI can cause inconclusive results. We were told they were inconclusive due to low fetal fraction and ended up doing a CVS. I'm 36 weeks now. Learn more about, Twins & Multiples: Your Tentative Time Table. (https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC3893900/). Oh overall not just gender lol I wish it were twins but I already had a few ultrasounds and saw the single baby. I didn't do a NIPT (just the NT scan) so no personal experience! I am assuming they will suggest more invasive testing? The views expressed in community are solely the opinions of participants, and do not reflect those of What to Expect. Whether patients are referred to us or already have a Cleveland Clinic ob/gyn, we work closely with them to offer treatment recommendations and follow-up care to help you receive the best outcome. 107 0 obj <>stream I had a d and c and fell pregnant immediately. Noninvasive prenatal testing (NIPT) has become popular with many physicians in screening pregnant patients. Even though my OB told me it likely wasn't the case for me, I was still in panic mode for a while. So bizarre this happens. However, they got all the ones they needed for the NIPT which were good. Ans to top it off I really wanted to find out the gender and now I dont even know if things are ok. We had anatomy scan this week and everything seems okay. Results from NIPT tests can sometimes take up to two weeks, although results are often available sooner. Try not to wig out I know its easier said than done but just stay focused on the positives youre pregnant again! When I called for test results over a week later, they said they had needed to test the second tube as the first had failed. If your baby still has a heartbeat now, maybe that means that the baby doesnt have that. Yes with Natera Panaroma, I had inconclusives twice & declined the third redraw. He sent me to do echocardiography which also was good and show no signs for pathologies. My baby is in under 5th percentile and doc says it looks like there are severe growth restrictions and an abnormally big head/small body ratio so I think that once we have the CVS answer we will have to man up and make decisions as I hate to think that that it may be in pain etc. Group Owners uphold the core values of the brand by reporting content that violates the community guidelines. Mine came back inconclusive twice. : Your healthcare provider will provide information about prenatal genetic testing and help you make an informed choice about your options. I have a high risk of 1/175. They told me since I am now 16w, I can send the quad screen to test for the trisomies and spina bifida. Understanding what the NIPT test results mean. New comments cannot be posted and votes cannot be cast. What is noninvasive prenatal testing and what disorders can it screen for? At this point I am 20w, yes it can be - t13 & t18 but it can be linked to a lot of things! They could have also just waited until 16 weeks for my first blood draw given my weight. I would be very frustrated. Id say if you dont have any family history of issues I bet youll be fine. Remember, only you and your family can decide whats best for you. Create an account or log in to participate. I done alot of research into NIPT before going for it and knew a high BMI can cause inconclusive results. Anyone else go through this and get good results? And like pp said.I hope your anatomy scan is smooth sailing and you can see that the baby is fine and healthy. My nipt/panorama/harmony results came back inconclusive both times. If noninvasive prenatal testing indicates that the fetus is at risk for a chromosomal disorder, your provider may recommend diagnostic testing. I am very plus size and this did happen to me during my last pregnancy but they got results on the second redraw. Be sure to understand what the test screens for and what the results mean so you make an informed decision. Taylor-Phillips S, Freeman K, Geppert J, et al. Based on the results of the NIPT test, your obstetrician may recommend diagnostic tests. I did an amnio today. Create an account to follow your favorite communities and start taking part in conversations. Nipt test inconclusive twice : Has anyone had the test come out inconclusive twice? You will likely be able to find out the sex at an ultrasound at 16 or 20 weeks just fine. I found out we are having a little girl! n_qTz For the most . Same thing happened to me. 2005-2023Everyday Health, Inc., a Ziff Davis company. I pray that everything is good with your little one, if your scans looks good then there is a lot of hope that its all going to work out for you! The first test they ran apparently i did not have enough fetal DNA i took another one and the same results, should I be concerned? Its important to remember that a screening test estimates the likelihood of the fetus having a particular condition. No idea what that means. NIPT is about 99% accurate in detecting Down syndrome. Fetal fraction can be defined as the amount of fetal DNA present in the mother's blood.
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